WEB108 Role of Collagen Oxidized Regenerated Cellulose (CORC) in Chronic Wounds
Released May 11, 2017
Expires May 11, 2019
Non-healing wounds are stuck in the inflammatory phase of healing and there are many factors that affect healing and contribute to this hostile wound environment. These factors include an excess of proteases and bacterial bioburden which should be controlled if the wound is to progress to healing.
The combination of collagen, oxidized regenerated cellulose and silver provides an ability to reduce these factors without having any detrimental effect on the host cells required for healing. Published studies have shown that Collagen/ORC/Silver can help reduce inflammatory based and bacterial protease activity in vitro. Similarly publications have found collagen/ORC/Silver to be more effective at reducing bacteria in biofilms in vitro in comparison to other silver, iodine or PHMB based materials. Collagen/ORC/Silver, was also the only silver dressing of those tested to provide the antimicrobial benefits of silver without harming cell growth in vitro.
Clinical studies have established that collagen/ORC helps promote healing and in the case of collagen/ORC/silver can also protect the wound against infection.
Physicians, PAs, NPs, Nurses, Discharge Planners, Admissions Coordinators, Social Services.
Upon completion of program: Identify the phases of wound healing and the mechanisms of inflammation. Recognize the wound which has stalled in healing due to excessive inflammation. Describe clinical strategies to treat excessive inflammation. Demonstrate that implementation of appropriate management algorithms improves patient healing and clinical outcomes. Demonstrate team based communication that will foster implementation of appropriate management algorithms resulting in improved patient healing and clinical outcomes. Handouts
Role of Collagen Oxidized Regenerated Cellulose (CORC) in Chronic Wounds Presentation Slides
Breda graduated from the Queen’s University of Belfast in Northern Ireland with BSc(Hons) and PhD in biochemistry, before going to Stony Brook University New York to undertake a postdoctoral position, studying the wound environment in non-healing wounds.
In 1994 Breda joined Johnson & Johnson and continued her work in wound care, most notably providing key scientific support for PROMOGRAN, PROMOGRAN PRISMA for which she was awarded the Johnson Medal, the highest scientific award recognized within Johnson and Johnson.
Breda has worked in industry for over 20 years continuing to advance clinical and scientific knowledge in the field of wound care. This has led to over 30 patents, and over 75 scientific publications and posters.
Breda Cullen, PhD is an employee of Systagenix.
Ruchit Parikh, PharmD Associate Medical Director Haymarket Medical Education
Dr. Parikh has no relevant financial relationships to disclose
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