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WEB108 Role of Collagen Oxidized Regenerated Cellulose (CORC) in Chronic Wounds

1.00 Credits

Released May 11, 2017

Expires May 11, 2019

Program Description

Non-healing wounds are stuck in the inflammatory phase of healing and there are many factors that affect healing and contribute to this hostile wound environment. These factors include an excess of proteases and bacterial bioburden which should be controlled if the wound is to progress to healing.

The combination of collagen, oxidized regenerated cellulose and silver provides an ability to reduce these factors without having any detrimental effect on the host cells required for healing. Published studies have shown that Collagen/ORC/Silver can help reduce inflammatory based and bacterial protease activity in vitro. Similarly publications have found collagen/ORC/Silver to be more effective at reducing bacteria in biofilms in vitro in comparison to other silver, iodine or PHMB based materials. Collagen/ORC/Silver, was also the only silver dressing of those tested to provide the antimicrobial benefits of silver without harming cell growth in vitro.

Clinical studies have established that collagen/ORC helps promote healing and in the case of collagen/ORC/silver can also protect the wound against infection.

Intended Audience

Physicians, PAs, NPs, Nurses, Discharge Planners, Admissions Coordinators, Social Services.

Learning Objectives

Upon completion of program: Identify the phases of wound healing and the mechanisms of inflammation. Recognize the wound which has stalled in healing due to excessive inflammation. Describe clinical strategies to treat excessive inflammation. Demonstrate that implementation of appropriate management algorithms improves patient healing and clinical outcomes. Demonstrate team based communication that will foster implementation of appropriate management algorithms resulting in improved patient healing and clinical outcomes. Handouts

Role of Collagen Oxidized Regenerated Cellulose (CORC) in Chronic Wounds Presentation Slides


Breda graduated from the Queen’s University of Belfast in Northern Ireland with BSc(Hons) and PhD in biochemistry, before going to Stony Brook University New York to undertake a postdoctoral position, studying the wound environment in non-healing wounds.

In 1994 Breda joined Johnson & Johnson and continued her work in wound care, most notably providing key scientific support for PROMOGRAN, PROMOGRAN PRISMA for which she was awarded the Johnson Medal, the highest scientific award recognized within Johnson and Johnson.

Breda has worked in industry for over 20 years continuing to advance clinical and scientific knowledge in the field of wound care. This has led to over 30 patents, and over 75 scientific publications and posters.

Faculty Disclosure

Breda Cullen, PhD is an employee of Systagenix.

CME Reviewer

Ruchit Parikh, PharmD Associate Medical Director Haymarket Medical Education

Dr. Parikh has no relevant financial relationships to disclose

Accredited Provider Disclosure

Haymarket Medical Education staff involved in the planning and content review of this activity have no relevant financial relationships to disclose.

Accreditation Statement

Haymarket Medical Education is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

Designation Statement

Haymarket Medical Education designates this enduring material for a maximum of 1.0 AMA PRA Category 1 CreditTM. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Disclosure of Unlabeled Use

This CME activity may or may not discuss investigational, unapproved, or off-label use of drugs. Participants are advised to consult prescribing information for any products discussed. The information provided in this CME activity is for continuing medical education purposes only and is not meant to substitute for the independent medical judgment of a physician relative to diagnostic and treatment options for a specific patient’s medical condition.


The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of Haymarket Medical Education and Acelity. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.

If you have any questions relating to the accreditation of this activity, please contact cmequestions@haymarketmedical.com


To obtain credit, a score of 70% or better on the post-test is required. This activity is offered at no cost to participants. Please proceed with the activity until you have successfully completed this program, answered all test questions, completed the post-test and evaluation, and have received a copy of your credit certificate.


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